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Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines; other agents may have antihistaminergic action but are not true antihistamines.In common use, the term "antihistamine" refers only to H In type I hypersensitivity allergic reactions, an allergen (a type of antigen) interacts with and cross-links surface Ig E antibodies on mast cells and basophils.H1 receptors are associated with human tissue involving capillaries, and H2 receptors predominate in the lining of the stomach.Even the best antihistamines do not offer anything in terms of permanent relief, nor do they relieve nasal congestion.

Once released, the histamine can react with local or widespread tissues through histamine receptors.Oral antihistamines are the most commonly prescribed allergy medication.Finding the best antihistamines can sometimes be a confusing issue, since so many OTC and prescription choices are available.Additional administration of epinephrine, often in the form of an autoinjector (Epi-pen), is required by people with such hypersensitivities.H-antihistamines can be administered topically (through the skin, nose, or eyes) or systemically, based on the nature of the allergic condition.That means you can control your symptoms with only 1 or 2 doses each day compared with older medications, which usually require doses every 4 to 6 hours to maintain their effectiveness.

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